The civil war in Syria continues to devastate social and political structures, precipitating floods of refugees and surging populations of internally displaced people. Syria has degenerated into sectarian- and ethnic-based warring mini-states vying for power as their country faces utter social disorder. It mass-produces a growing cadre of battle hardened foreign and domestic jihadists affiliated with the various al-Qaeda brands. The war weariness of America and the unmanageable chaos in Syria combine to create shifts in regional politics. This article seeks to put into perspective the crucial role that regional mediation can play in nudging along practical solutions. Without regional commitment and coordination among key Middle Eastern powers, namely Iran, Saudi Arabia and Turkey, international diplomatic efforts to restore order and stability in Syria are not likely to succeed.