The American-centric world order that was shaped after the end of the Cold War is being questioned by dynamically growing “old” and “new” centers of power, namely Russia and China. Entities united in opposition to American hegemony pursue policies that challenge not only the U.S. position but more importantly American interests. This process has been especially visible in the wake of the civil war in Syria. This article aims to analyze the U.S. Middle East strategy in the context of ongoing redistribution of power in the region, influenced by the Iran-Russia-Türkiye triangle. It claims that Syria’s civil war stimulated the formation of this triangle and significantly influenced the further evolution of the balance of power in the region, posing both a direct challenge and an indirect threat to the American position and its interests in the Middle East. The article argues for the necessity of correcting the American Middle East strategy, as the one implemented so far opened the door to other powers to compete for influence in the Middle East.