This article analyzes how Turkey should adjust its grand strategy under the changing international order. It claims that the international order has undergone a significant transformation that is pushing Turkey to relocate its international position. First, the article examines the characteristic features of the changing dynamics of the international system; it then sheds light on the new aspects of Turkey’s changing strategic landscape. By taking into consideration the transformation in Turkish foreign and security policy since the Arab Uprising, the article argues that Turkey needs a basis for determining what is important and what is not, what the primary threats to the nation’s interests are, and how best to serve those interests in a way that is attentive to the costs and risks it is willing to bear. Our aim in this article is to describe how Turkey can deal with the new reality of the international system and pursue and protect its important interests by developing a comprehensive grand strategy.