This paper examines the commercial opportunities that will endure in key sectors for the United States and Turkey in the midst of the coronavirus pandemic and its aftermath. These sectors include financial services and capital markets; supply chains and logistics; healthcare; digital economy; defense and aerospace; energy; travel and tourism; and women in business. While defense and security ties have traditionally led the U.S.-Turkey relationship, this piece argues that the pandemic offers the two countries mutual benefits from more robust economic and commercial cooperation in less prominent sectors such as healthcare, the digital economy, and finance.