In this paper, I argue that a fuller understanding of the recent activism in Turkish foreign policy, and in particular the changing nature of relations with its neighbors, requires us to engage in the study of the increasing economic interdependence and the analysis of broadly redefined national interests. Therefore, this paper aims to explain Turkey’s relations with its neighbors through the neo-liberal theory model put forth by Robert O. Keohane and Joseph S. Nye, which underlines the importance of interdependence and cooperation among states. I argue that recent developments in Turkish foreign policy, particularly Turkey’s relations with its neighbors, resemble the characteristic features of complex interdependence. The new activism in Turkish foreign policy facilitates international cooperation among regional actors and creates a “complex interdependence”.