This paper aims to forecast the route that Joe Biden, will take in his foreign policy toward the Eastern Mediterranean, by trying to analyze the content of his speeches and rhetoric before and shortly after taking office. In this context, America’s relation to Turkey will be pivotal in order to gauge the impact of any change in U.S. course. After four years of Trump’s doctrine of ‘America First’ and his bilateral approach, there are many expectations that the newly elected president will follow a more multilateral approach and will put more importance on international organizations and alliances across the Atlantic. Those expectations are more like wishes, however, when it comes to the Eastern Mediterranean, which is on the verge of a critical standoff between Turkey and its neighbors. There are some speculations that Biden will take a more affirmative stance against Turkey. Indeed, Biden has stressed the value of cooperating with allies to achieve foreign policy objectives. But despite the harsh language, Biden used during his election campaign to describe Turkey’s leadership, it is still unclear whether Biden will place the U.S. on a collision course with Turkey.