The international community is worried about the security implications of Iran’s nuclear activities. Although it has been argued that Iran is very close to make a nuclear bomb, the results of the latest official reports from the International Atomic Energy Agency (IAEA) and some American intelligence institutions demonstrate that Iran is not reluctant to consider the concerns of the international community in its decisions. One of the main policies of great powers is to cooperate with regional actors, like Turkey, to persuade Iran to be more flexible in its nuclear policy and particularly in its uranium enrichment activity. The historical mistrust between Iran and the great powers reinforces the necessity of having other regional actors act as mediators and countries like Turkey can play an important role in this context. The governing AKP’s mediation policy in the regional level is a catalyst to Turkey’s attempts to mediate between Iran and the 5+1 Group, although mediation can have its own difficulties.